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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GYS1
All Species:
20
Human Site:
S486
Identified Species:
31.43
UniProt:
P13807
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13807
NP_002094.2
737
83786
S486
P
E
F
L
S
S
T
S
P
L
L
P
V
D
Y
Chimpanzee
Pan troglodytes
XP_520790
703
80912
R462
P
I
L
S
T
I
R
R
I
G
L
F
N
N
R
Rhesus Macaque
Macaca mulatta
Q8MJ26
737
83768
S486
P
E
F
L
S
S
T
S
P
L
L
P
V
D
Y
Dog
Lupus familis
XP_534869
703
80957
R462
P
I
L
S
T
I
R
R
I
G
L
F
N
S
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1E4
738
83908
S486
P
E
F
L
S
S
T
S
P
L
L
P
V
D
Y
Rat
Rattus norvegicus
A2RRU1
738
84053
S486
P
E
F
L
S
S
T
S
P
L
L
P
V
D
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505471
733
83148
S486
P
E
F
L
S
S
T
S
P
L
L
P
V
D
Y
Chicken
Gallus gallus
XP_416432
704
81032
I461
N
D
P
I
L
N
T
I
R
R
I
G
L
F
N
Frog
Xenopus laevis
NP_001084863
702
80811
V461
T
D
P
I
L
N
T
V
R
R
I
G
L
F
N
Zebra Danio
Brachydanio rerio
NP_957474
700
80455
I460
S
D
P
I
L
N
C
I
R
R
I
G
L
F
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFC8
709
81735
R461
D
D
L
V
K
I
K
R
C
M
F
A
M
Q
R
Honey Bee
Apis mellifera
XP_624707
692
79590
G451
L
Y
A
L
Q
R
N
G
L
P
P
V
T
T
H
Nematode Worm
Caenorhab. elegans
Q9U2D9
672
76441
G433
I
F
D
I
C
L
Q
G
H
L
P
E
P
E
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23337
708
80492
S469
V
R
L
F
N
D
S
S
D
R
V
K
V
I
F
Red Bread Mold
Neurospora crassa
O93869
706
80888
F467
S
D
R
V
K
I
V
F
H
P
E
F
L
S
S
Conservation
Percent
Protein Identity:
100
68.6
99
69.3
N.A.
96.6
96.6
N.A.
90
71
69.3
78.1
N.A.
55
56.4
49.6
N.A.
Protein Similarity:
100
81.8
99.5
82.5
N.A.
98.5
98.5
N.A.
95.2
84.1
82.5
86.5
N.A.
71
70.1
65.8
N.A.
P-Site Identity:
100
13.3
100
13.3
N.A.
100
100
N.A.
100
6.6
6.6
0
N.A.
0
6.6
6.6
N.A.
P-Site Similarity:
100
26.6
100
20
N.A.
100
100
N.A.
100
40
40
33.3
N.A.
26.6
13.3
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
50
51.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
67.1
67
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
7
0
7
0
7
0
0
0
0
0
0
% C
% Asp:
7
34
7
0
0
7
0
0
7
0
0
0
0
34
0
% D
% Glu:
0
34
0
0
0
0
0
0
0
0
7
7
0
7
7
% E
% Phe:
0
7
34
7
0
0
0
7
0
0
7
20
0
20
7
% F
% Gly:
0
0
0
0
0
0
0
14
0
14
0
20
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
14
0
0
0
0
0
7
% H
% Ile:
7
14
0
27
0
27
0
14
14
0
20
0
0
7
0
% I
% Lys:
0
0
0
0
14
0
7
0
0
0
0
7
0
0
0
% K
% Leu:
7
0
27
40
20
7
0
0
7
40
47
0
27
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% M
% Asn:
7
0
0
0
7
20
7
0
0
0
0
0
14
7
20
% N
% Pro:
47
0
20
0
0
0
0
0
34
14
14
34
7
0
0
% P
% Gln:
0
0
0
0
7
0
7
0
0
0
0
0
0
7
0
% Q
% Arg:
0
7
7
0
0
7
14
20
20
27
0
0
0
0
20
% R
% Ser:
14
0
0
14
34
34
7
40
0
0
0
0
0
14
7
% S
% Thr:
7
0
0
0
14
0
47
0
0
0
0
0
7
7
0
% T
% Val:
7
0
0
14
0
0
7
7
0
0
7
7
40
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
34
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _